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Contents:
- Pathophysiology of atherosclerotic vascular disease
- Pathophysiology and treatment of hypertension
- Gout-Osteoporosis
- Lipid metabolism and pathophysiology of dyslipidemias
- Metabolic syndrome
- Disorders of sodium and potassium
- Acid-base disorders
- Diabetes mellitus (diagnosis, complications, treatment),
- Other metabolic diseases (porphyrias, hemochromatosis, Wilson's disease, glucagen storage disease, lipodystrophies, Gaucher's disese)
Teaching: Teaching is provided by 2-hour lectures every week. This elective course is devoted to further understanding of a variety of metabolic diseases, which are very common at the clinical setting. Emphasis is put on atherosclerotic vascular disease and associated main risk factors. Another major topic is acid-base and electrolyte disorders, which are always a challenge for the physician.
Hours of training per student: 26
From the 10th Semester
ECTS: 2
Objectives of the course: The course offers gaining of knowledge regarding the diagnosis and management of acute and chronic myeloid leukemia, that also includes basic knowledge of applied molecular biology, use of the microscope, transfusion medicine, diagnosis and management of infections in the immunocompromised patient, basic principles of allogeneic transplantation and basic principles of clinical research.
Contents of the course: Epidemiology and WHO Classification of Leukemias. Clinical presentation and molecular mechanism of leukemogenesis, breaking bad news, discussing the diagnosis and prognosis. Diagnosis of leukemia/Blasts: morphology in the peripharal blood and bone marrow smear. Allogeneic haematopoetic stem cell transprantation: basic priciples, indications and procedure. Treatment options. Application of cytogenetic and molecular analyses: qPCR, minimal residual disease. Videos of procedures: venpucture, bone marrow aspirate and biopsy, central catheter. Clinical and translational research, international research networks. Demonstartion of flow cytometry in an acute leukemia sample (group of 3 students), demonstration of biobanking, detection of PML/RARa transcript by PCR (group of 3 students). Demostration of peripheral blood and bone marrow smear microscopy (8-10 smears from patients with acute or chronic myeloid leukemia). Participation in a bone marrow biopsy precedure. Participation in the diagnosis and management of a patient with leukemia. Participation in the prescription and administration of cytotoxic chemotherapy and hypomethylating treatment.
Mode and outcomes of teaching: The course is tought in combination with clinical and laboratory practice in groups of 3-4 students. At the end of the course the students should be able to recognize the clinical and laboratory presentation of leukemia, to discuss with the patient and the relatives regarding the diagnosis and prognosis of the diesease, to perform a bone marrow biopsy, to gain basic experience in molecular techniques, to prescribe a cytotoxic regimen, to know how to search for literature regarding a certain subject.
Hours of training per student: 27
From the 10th Semester
ECTS: 2
Scope: teaching of different endocrine gland disorders based on common pathogenetic mechanisms so that the student may better understand the clinical features of diseases and syndromes that may affect multiple endocrine glands.
Course Syllabus:
1. Organ-specific autoimmunity
- principles
- polyglandular autoimmune syndrome (type I, II, III)
- autoimmune thyroid disease
- autoimmune diabetes mellitus (type 1, LADA)
2. Endocrine gland Hyperplasia/Neoplasia
- mulpiple endocrine neoplasia syndrome (type 1 and type 2)
- nodular thyroid disease
- adrenal incidentaloma
3. Target organ resistance to hormone actions
- steroid/sex hormone resistance
- thyroid hormone resistance
- peptide hormone resistance
4. Deficiency of enzymes of hormonogenesis - hormone metabolism
- deficiency of steroidogenesis enzymes
- deficiency of enzymes of thyroid hormone synthesis
- deficiency of enzymes of hormone metabolism
5. Disorders of energy/glucose homeostasis
- the role of fatty tissue on energy homeostasis
- lipodystrophies
- insulin resistance -type 2 diabetes
6. Disorders of bone metabolism
- hormonal regulation of bone metabolism
- vitamin D – pleiotropic actions
- osteomalacia – osteoporosis
Teaching format and outcomes: At the end of each teaching module, presented with the use of electronic aids, a number of relevant clinical cases will be presented and discussed. This will enable the student to obtain an integrated view of the different clinical entities. In parallel, those students who may be interested are given the option to present a review of the literature in a topic of their choice, related to the field of endocrinology and diabetes. At the end of the teaching program, these projects are presented by the students to their teachers and fellow students.
Hours of training per student: 26
From the 10th Semester
ECTS: 2
Aim of this syllabus: Providing theoretical knowledge to the medical students about adolescence since it presents many differences, from childhood and adulthood.
Lecture topics: Adolescents' characteristics. Growth pattern (growth retardation, accelerating growth). Psychosocial and mental development. Hormonal development-puberty Tanner's stages. Puberty disorders (early puberty, delayed puberty). Eating disorders: anorexia nervosa, bulimia, obesity. High risk behavior: alcohol, drugs, violence, risky sexuality, smoking, driving with no experience, use of diet supplements, doping. Depression, suicidal ideation. Breast disorders (ectopic nipples, absence of nipples, benign-malignant tumors). Vaccinations during adolescence. Infectious diseases. Hypertension. Sexual infectious diseases. Skin problems (acne, psoriasis). Male genital abnormalities. Neoplastic and blood diseases. Transition from adolescence to adulthood. Internet (use, addiction, safety). Adolescence and sports. Chronic diseases.
Plan and outcomes of teaching: The lectures are given twice a week, while there is a teaching round in the wards of Pediatrics and the outpatient clinics during a twelve-week period. Students acquire theoretical and practical knowledge under the supervision of the tutor and all academic staff as to be able to approach the diagnosis of the majority of disorders in adolescence.
Hours of training per student: 26
From the 10th Semester
ECTS: 2
Course objective: To present basic principles and special issues of gynecological oncology.
Course content: Neoplasms of vulva and vagina. Cervical cytology and pathology: molecular markers. HPV vaccination, CIN and cervical cancer. Conservative treatment of uterine neoplasms. Sentinel lymph node in gynecological oncology. Fertility preservation in gynecological oncology. Borderline ovarian tumors. Molecular basis of ovarian cancer. Benign and malignant breast tumors: the role of oncoplastic surgery and axillary lymph node dissection. Molecular biology of tumorigenesis.
Teaching: Lectures. Students are expected to reach an adequate level in assessing a gynecological oncology patient and orient themselves during a relevant surgical operation. At the end of the course students are expect to deliver a review of the literature upon common gynecological oncology.
Hours of training per student: 26
From the 10th Semester
ECTS: 2