"Stem cell applications in understanding and treating Parkinson's disease"

Abstract

Parkinson’s disease is the second most common neurodegenerative disorder. The pathological features of Parkinson’s disease include the progressive loss of function of the dopaminergic neurons of the brain’s substantia nigra and their subsequent cell death. While advances in the understanding of pathogenesis and epidemiology are significant, the cause of Parkinson’s disease remains enigmatic and no effective or preventive treatment has yet been found. In this diploma thesis, a bibliographic review was conducted of the research concerning the use of stem cells for the understanding (preclinical research of biological mechanisms) of the etiology of Parkinson’s disease and their use for the creation of dopaminergic neurons used for therapeutic transplantation.

In conclusion, Regenerative Medicine through induced pluripotent stem cells attempts to open new directions for the treatment of Parkinson’s disease.

NTALIPI Natalia