Objectives of the course: Going deeper in major aspects of "Pharmacokinetics" as well as the connection between "pharmacokinetics" and "pharmacodynamics".

Contents of the course: Lessons will be given in relation to the following subjects:

• Clearance, Volume of distribution, Half-Life
• How Drugs Cleared by the Liver
• Bioavailability and First-Class Clearance
• Predicting Drug Interactions and the Effects of Disease States for Metabolised Drugs
• Clearance of Drugs by the Kidneys
• Drug Protein Binding
• Non-Linear Pharmacokinetics
• How to Determine the Pharmacokinetic Parameters of a Drug
• Pharmacodynamics: The Concentration-Effect Relationship
• Designing Dose Regimens
• Therapeutic Drug Monitoring

In addition, pharmacokinetic problems are solved using simple equations.

Mode and outcomes of teaching: The 3-weeks course is built on different axes: lectures, practical and educational - calculation software.

At the end of the course the students should be able to calculate pharmacokinetic parameters for a clinical study, prepare figures from PK data, estimate and understand PK parameters from a clinical study. Student will use data from clinical studies conducted in the Department of Pharmacology.

Hours of training per student: 26

From the 5th Semester

ECTS: 2