Efstathios Frillingos

Efstathios Frillingos

Professor

Contact

Telephone

+30 26510 07715

Email

Collaboration schedule

Monday 11.00-13.00
Tuesday 11.00-13.00
Wednesday 11.00-13.00

Address

Faculty of Medicine
Health Sciences School
University of Ioannina
University Campus
45110 Ioannina
Greece

Academic information

O.G.G. of Appointment

655/Γ'/10-7-2012

Personal webpage

PubMed

Curriculum Vitae

Field

Βιολογική Χημεία

Research areas

Basic Research
  • Σχέσεις δομής-λειτουργίας πρωτεϊνών διαμεμβρανικής μεταφοράς
  • Μεταφορείς νουκλεοσιδίων/νουκλεοτιδικών βάσεων και αντιμεταβολιτών τους
1.   Iosifidou A, Anagnostopoulou E, Botou M, Kalfa E, Tatsaki E, and Frillingos S. (2024). Elucidation of the gemcitabine transporters of Escherichia coli K-12 and gamma-proteobacteria linked to gemcitabine-related chemoresistance. Int. J. Mol. Sci. 25:7012
2.  Tatsaki E, Anagnostopoulou E, Zantza I, Lazou P, Mikros E, and Frillingos S. (2021). Identification of new specificity determinants in bacterial purine nucleobase transporters based on an ancestral sequence reconstruction approach. J Mol Biol  433:167329
3.  Botou M, Yalelis V, Lazou P, Zantza I, Papakostas K, Charalambous V, Mikros E, Flemetakis E, and Frillingos S. (2020). Specificity profile of NAT/NCS2 purine transporters in Sinorhizobium (Ensifer) meliloti. Mol Microbiol 114:151-171
4.   Botou M, Lazou P, Papakostas K, Lambrinidis G, Evangelidis T, Mikros E, and Frillingos S. (2018). Insight on specificity of the NAT/NCS2 family from analysis of the transporter encoded in the pyrimidine utilization operon of Escherichia coli. Mol Microbiol 108:204-19
5.     Karena E, Tatsaki E, Lambrinidis G, Mikros E, and Frillingos S. (2015). Analysis of conserved NCS2 motifs in the xanthine permease XanQ of Escherichia coliMol Microbiol 98:502-17
6.     Papakostas K, Botou M, and Frillingos S. (2013). Functional identification of the guanine/hypoxanthine transporters YjcD and YgfQ and the adenine transporters PurP and YicO of Escherichia coli K-12. J Biol Chem 288:36827-40
7.     Karena E, and Frillingos S. (2011). The role of transmembrane segment TM3 in the xanthine permease XanQ of Escherichia coli. J Biol Chem 286:39595-605
8.     Kaback HR, Dunten R, Frillingos S, Venkatesan P, Kwaw I, Zhang W, and Ermolova N. (2007). Site-directed alkylation and alternating access model for LacY. Proc Natl Acad Sci USA 104:491-494
9.     Karatza P, and Frillingos S. (2005). Cloning and functional characterization of two bacterial members of the NAT/NCS2 family in Escherichia coliMol Membr Biol 22:251-61
10.  Frillingos S, Sahin-Toth M, Wu J, and Kaback HR (1998). Cys-scanning mutagenesis: a novel approach to structure-function relationships in membrane proteinsFASEB J 12:1281-1299