"Evaluation of the antibody response induced after vaccination with current COVID-19 vaccine technologies against SARS-CoV-2 in all population age groups"

Abstract

Aim: The evaluation of the antibody response induced after vaccination in the population with a plenty of variant COVID-19 vaccine technologies against SARS-COV-2, and the duration of immunity.

Methods: The present study was a literature review of the current scientific research evidence. Online searches were carried out in the PubMed and Medline search engines, in May- Ocober 2022. The search included various terms (keywords) and a combination of these terms in Greek and English to identify and display articles which would be as close as possible to the research subject.

Results: 125 articles were found. 50 of these were judged as eligible sources from the title and abstract presented to extract general information while 40 of them were selected for inclusion in the literature review. Each technology platform has its own advantages and challenges related to its ability to elicit robust immune responses, productivity, and safety for clinical use. In the context of the response to the COVID-19 pandemic, all types of technology platforms for vaccine development have been evaluated, thereby increasing the chances that at least some of the vaccine candidates will be approved and brought to market.

Conclusion: Vaccination against SARS-COV-2 has been fundamental in reducing deaths during the various phases of the pandemic and contributed to the defense of public health. Although at least 1–2 years are required for effective vaccines to be available worldwide, vaccination may still be the fastest and most cost-effective strategy to achieve broad immune protection.

MOULOPOULOU Panagiota