"Αntibiotic resistant of Klebsiella pneumoniae"

Abstract

Klebsiella pneumoniae is a major multidrug-resistant pathogenic bacterium (MDR) and is an important source of hospital infections associated with high morbidity and mortality.

Over the last few decades, there has been an increase in the resistance of K. pneumoniae strains to a wide range of antibiotics mainly due to acquired resistance genes: KPC, MBL, NDMand OXA-48. Antibiotics used to treat infections are β-lactam antibiotics, such as cephalosporins, carbapenems, alone or in combination with β-lactamase inhibitors, and others as tigecycline, polymyxins, quinolones and aminoglycosides. Diagnostic investigation is based on phenotypically and molecular methods. The epidemiological study proves that there is a worldwide spread, sporadic and/or endemic. Recognizing unique markers for specific high-risk clones will help to effectively identify carriers, prevent transmission, and to improve diagnosis.

KOUPIDOU Georgia