"The role of the protein Hsp70 in epithelial-mesenchymal Transition (EMT)"

Abstract

Two of the most common problems in various types of cancer are resistance to chemotherapy and the ability of cancer cells to infiltrate and migrate to other healthy tissues. In an effort to create more effective therapies, the role of HSP70 in carcinogenesis, metastasis and EMT has been extensively studied. The EMT process is the main process of conversion of epithelial cells into mesenchymal cells that have the ability of cell movement. HSP70 has been observed to be overexpressed in various types of cancer and to be expressed externally on their cytoplasmic membrane leading to the formation of extracorporeal. Targeting HSP70 has been a field of study in recent years, with inhibitors reaching as far as phase 2 clinical trials. Targeting HSP70 in combination with conventional chemotherapy appears to lead to the development of an effective metastatic regimen against metastatic cells and cells with resistance to chemotherapy and radiotherapy.

TZIMA Xristina