Objectives of the course: The course offers gaining of knowledge regarding the control principles of the internal environment, substances transfer through biological membranes, functional morphology nervous and muscle cells, mechanisms hematopoietic system and digestive system mechanisms and their disorders.

General cellular Physiology Homeostasis: Control of internal enviroment, Concentrations electrolytes in body fluids. Structure membrane-formation and properties lipid bilayer, Substances transport through membrane, Membrane polarization, Passive transport, Primary-Secondary active transport, Epithelial transport. Channels, pumps, Nerve cell Functional morphology, membrane potential, action potential, Functional structure striated and smooth muscles, Cardiac Muscle, Muscle contraction, Neuromuscular junction, neuromuscular junction drugs, Peripheral nerves, Neurotransmitters.

Hematopoietic system: General functions blood - Erythrocytes- haematological indicators-Factors erythropoiesis, Iron metabolism, Iron deficiency anemia, Aplastic anemia, Megaloblastic anemia, Hemolysis –Hemolytic anemias, Leucocytes, Inflammation , Immune system, immune reaction – Allergic responses, -Blood transfusion, Blood Groups, Rhesus incompatibility, Platelets , Coagulation mechanism, Fibrinolysis, Haemorrhagic and Thromboembolic cases, Anticoagulants, Bone marrow, Reticuloendothelial system, Serum proteins, Edema, Hemoglobin biosynthesis, Hemoglobin degradation, thallasemia , Jaundice, Bile pigments.

Digestive system: General principles digestive function. Splanchnic circulation. Control mechanisms (smooth muscle, neural and hormonal control). Mouth, Pharynx, Esophagus (chewing, swallowing, salivary secretion).

Stomach: Anatomical functional characteristics, Processes of Motility, secretion, regulation mechanisms, mucosal barrier. Processes of secretion in the Exocrine Pancreas. Liver, Gall bladder, Processes of secretion in the biliary system. Processes of motility, secretion, absorption in the Small intestine (Duodenum, Jejunum, Ileum). Processes of absorption, secretion, motility in the Large intestine. Metabolism. Thermoregulation.

Mode and outcomes of teaching: The course is tought in combination with laboratory exercises, concerning hematopoietic and digestive system, as well as student group presentations on topics hematopoietic system. At the end of the course students should be able to recognize, disturbances in blood picture, leukocytes, hemostasis, anemias types, jaundice and knowledge regarding on mechanisms digestive system and their disorders.

Hours of training per student: 104

Semester: 2nd

ECTS: 7