Object: Studying of Pharmacogenomic issues, offers the possibility to obtain knowledge related to the impact of genomic variants on the pharmacodynamic and pharmacokinetic properties of selected drug therapy. Studying of available evidence on the clinical application of Pharmacogenomics provides knowledge which identifies and describes the potential of individualized therapy in order to maximize efficacy and/or minimize toxicity.

Content:

• Basics in Pharmacogenomics-Genomics
• Pharmacogenomics and Drug Development
• Clinical Application of Pharmacogenomics – Pharmacogenomic testing for selected medication - Goal-Directed therapies
• Ethical, social, legal and economic issues

Teaching methods and outcomes: This course includes 6 lectures, 1 laboratory class, 4 group meetings and a final meeting (presentation day) characterized as a mini-symposium. Students are given an article which is going to be presented at the last "presentation day".

After completing this course the students will be able: a) to identify the impact of genomic variants on drug dosing, efficacy and/or toxicity, b) to describe currently available evidence on pharmacogenomic tests for selected medications, c) to discuss the recommendations of pharmacogenomic testing for selected medications, d) to state challenges and limitations of pharmacogenomics in clinical practice, and d) finally, to identify the role of pharmacogenomics on Drug Development.

Hours of training per student: 26

From the 5th Semester

ECTS: 2