Objectives of the course: Understanding the molecular mechanisms by which Free Radicals and other Reactive Oxygen Species are involved in the initiation and the development of serious pathological conditions, such as cardiovascular and neurodegenerative diseases, cancer, ischemia reperfusion syndrome and the normal process ageing.
Contents: Introduction to Free Radicals: Definition and chemical properties of free radicals. Oxidative Stress. Formation of Free Radicals in cells. Biochemical mechanisms of free radical-induced cytotoxicity. Defense mechanisms in cells. Reactive Oxygen Species as physiological mediators in signal transduction. Oxidative stress and apoptosis.
Teaching format and learning outcomes: Teaching is implemented through lectures. Students are expected to familiarize with molecular mechanisms of generation and removal of Free Radicals and other Reactive Oxygen Species in the cells. In this context, it is important for the students to consolidate that Free Radicals and Oxidative Stress are implicated in the induction and development of serious pathological conditions.
Hours of training per student: 26